Introduction
Fractures and slow bone healing are among the most common challenges faced by adults as they age. As early as our 40s and 50s, changes in hormone levels, nutrient absorption, and cellular signaling begin to alter the natural rhythm of bone turnover—the delicate balance between bone breakdown and renewal.
OsteoFrax™ was developed to support this natural bone repair cycle. Combining clinically studied botanical extracts and essential bone-supportive nutrients, it aims to assist the body’s innate ability to repair, regenerate, and maintain strong, resilient bone tissue.
This article reviews what OsteoFrax™ is, how its key ingredients work, the evidence supporting their use, and what research tells us about safety and effectiveness.
The Biology of Bone Repair and Why It Slows With Age
Bone is a living tissue constantly being renewed through bone remodeling, a process involving two primary cells: osteoclasts, which break down old or damaged bone, and osteoblasts, which build new bone tissue. In youth, these processes are balanced. As we age, this balance shifts toward greater resorption, leading to gradual loss of bone density and slower healing following stress or fracture.
Aging also increases oxidative stress and chronic low-grade inflammation—both of which can interfere with osteoblast activity (1). Postmenopausal hormonal changes compound the effect, accelerating the rate of bone turnover and reducing bone mineral density (BMD) (2).
Nutrients such as vitamin D, vitamin K2, and various plant-derived compounds have been studied for their ability to positively influence this bone remodeling environment. OsteoFrax™ brings together several of these compounds in a single formulation.
What Is OsteoFrax™?
OsteoFrax™ is a professional-grade dietary supplement formulated by Healthy Bones Co. to support the body’s natural bone repair and regeneration processes.* It contains four clinically studied components:
- OsteoCaf® (Dalbergia sissoo) — a standardized botanical extract from Indian rosewood leaves, studied for its osteogenic and anti-resorptive properties.
- Calzbone® (Cissus quadrangularis) — a traditional Ayurvedic extract validated in modern research for its fracture-healing support.
- Vitamin D3 (Cholecalciferol) — essential for calcium absorption and bone remodeling.
- Vitamin K2 (MK-7 from MenaQ7®) — helps direct calcium into bone tissue and away from arteries.
OsteoFrax™ is manufactured in the USA with U.S. and globally sourced ingredients, in a GMP-certified, FDA-registered facility, and undergoes third-party testing for purity and potency. It is Non-GMO, Gluten-Free, Dairy-Free, and Sugar-Free.
OsteoFrax™ Ingredient Evidence and Mechanisms of Action
1. Dalbergia sissoo (OsteoCaf®)
Dalbergia sissoo, commonly known as Indian rosewood, has been used in traditional medicine for centuries. Modern research has confirmed its potential role in promoting bone formation and reducing inflammatory processes that interfere with bone turnover.
In a 12-month open-label clinical study in postmenopausal women, standardized Dalbergia sissoo extract was associated with significant reductions in TNF-α, total alkaline phosphatase (ALP), and high-sensitivity C-reactive protein (hs-CRP), with bone mineral density maintenance across most measured sites (3).
Preclinical work demonstrates that Dalbergia sissoo constituents can stimulate osteoblast differentiation through BMP-2 and Wnt/β-catenin signaling pathways, both of which play essential roles in bone formation and remodeling (4,5). In animal models, extracts promoted cortical bone regeneration and showed both anti-resorptive and bone-forming effects (6,7).
Together, these findings suggest that OsteoCaf® may help create a biological environment favorable to bone regeneration and repair—particularly during periods of elevated turnover or recovery from fracture.*
2. Cissus quadrangularis (Calzbone®)
Cissus quadrangularis is another botanical with deep roots in traditional medicine, often called the “bone-setter plant” for its longstanding use in supporting skeletal healing. Modern investigations have validated many of these historical claims.
Clinical studies report that Cissus quadrangularis supplementation can accelerate fracture healing, increase callus formation, and improve biomechanical bone strength [8,9]. A 2024 systematic review and meta-analysis of human trials concluded that Cissus quadrangularis significantly improves bone-related biomarkers, including serum calcium, phosphorus, and alkaline phosphatase, with excellent safety and tolerability (10).
Mechanistically, this extract influences osteoblast activity, reduces oxidative stress, and modulates inflammatory cytokines—all factors that play crucial roles in bone recovery and remodeling (11).
When combined with Dalbergia sissoo, the synergistic effect is notable. In a randomized, controlled clinical trial comparing Teriparatide (a prescription anabolic agent) with a Cissus + Dalbergia combination, researchers found that the botanical combination produced the strongest early radiographic bone union and superior improvements in osteogenic markers within 8–12 weeks (12).
3. Vitamin D3
Vitamin D3 (cholecalciferol) is vital for calcium and phosphorus absorption in the intestines and for maintaining adequate serum calcium levels for bone mineralization. Deficiency in vitamin D is strongly associated with poor fracture healing and increased risk of falls and fractures in older adults (13).
Research consistently demonstrates that adequate vitamin D status supports the bone remodeling cycle and the function of osteoblasts and osteoclasts (14). Within the OsteoFrax™ nutrient system, D3 serves as the absorption catalyst—ensuring the minerals and cofactors available in the diet can actually reach bone tissue where they are needed most.*
4. Vitamin K2 (MK-7, MenaQ7®)
Vitamin K2 in the MK-7 form has been studied for its unique role in activating bone-building proteins, particularly osteocalcin and matrix Gla protein. These proteins are responsible for binding calcium within the bone matrix and preventing its deposition in soft tissues (15).
Three-year, low-dose trials of MenaQ7® MK-7 in healthy postmenopausal women demonstrated a reduction in age-related decline in bone mineral density and bone strength indices, and improvements in vitamin K status and osteocalcin carboxylation (16).
K2 effectively acts as the director in calcium metabolism—ensuring the mineral is delivered into bone tissue rather than accumulating elsewhere.*
Integrating the Evidence: OsteoFrax™ Supports Bone Regeneration from Four Angles
The OsteoFrax™ formulation integrates these nutrients into a four-phase model of support:
Absorb (D3) → Direct (K2) → Build (OsteoCaf®) → Repair (Calzbone®).
- Vitamin D3 enhances calcium absorption and bioavailability.
- Vitamin K2 (MK-7) directs absorbed calcium into the skeletal matrix.
- OsteoCaf® (Dalbergia sissoo) supports osteoblast formation and reduces inflammatory interference with bone growth.
- Calzbone® (Cissus quadrangularis) accelerates tissue regeneration and structural repair after fracture or stress.
