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Annatrol™ Bone Support

Annatrol™ Bone Support

Annatrol™ combines Annatto Tocotrienols and Geranylgeraniol (GG), two powerful nutrients that support healthy aging, cellular energy generation, oral health, a healthy inflammatory response, heart health, and maintenance of muscle and bone mass.*

In a randomized, double-blind, placebo-controlled study, 300mg of Annatto Tocotrienols decreased bone resorption (breakdown) and improved bone turnover rate in postmenopausal women.

Many studies have also confirmed that Geranylgeraniol (GG) is an essential building block that supports protein synthesis, muscle health, bone health, hormone regulation, and the synthesis of CoQ10 and MK-4 in our bodies.*

Annatrol™ Bone Support is 100% plant-based and provides the right amounts of Tocotrienols and GG to support your stronger bones goals. Add on Healthy Bones Co. Magnesium or D3/K2 to your order for a powerful combination!

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Dairy free

Gluten Free

GMO Free

Sugar Free

  • Benefits
  • Description
  • Recommended Use
  • Ingredients

The ingredients in Annatrol™ have decades of research behind them and many studies showing their benefits including multiple double-blind, randomized controlled trials. Potential benefits of Tocotrienols and Geranylgeraniol may include:

  • Maintenance of healthy muscles and bones*
  • Helps maintain skin and eye health*
  • Promotes cardiovascular and circulatory health*
  • Promotes regulation of healthy metabolic functioning*
  • Supports insulin sensitivity and normal glycemic control*
  • Promotes a healthy inflammatory response*
  • Supports antioxidant status*
  • Healthy liver function*
  • Mitochondrial function and cellular energy generation*
  • Hormone synthesis*
  • Proper cell membrane construction*
  • Provides support for healthy lipid profile and total cholesterol levels*

The ingredients in Annatrol™ are backed by studies including:

  • In an open label, dose escalation study, 250mg/day of annatto tocotrienols improved lipid parameters, inflammatory biomarkers, and oxidative stress in hypercholesterolemia subjects (1)
  • In a randomized, double-blind, placebo-controlled study, 300mg of annatto tocotrienols decreased bone resorption, and improved bone turnover rate in postmenopausal women. (2)
  • In a randomized, double-blind, placebo-controlled study, 250mg/day of annatto tocotrienols led to improved glycemic control accompanied by reduced inflammation, and oxidative stress, and further confirmed by modified miRNA expression. (3)
  • In a randomized, double-blind, placebo-controlled study, 300mg of annatto tocotrienols improved glycemic control in patients with prediabetes. (4)

References:

1) Qureshi, A. A., Khan, D. A., Mahjabeen, W., & Qureshi, N. (2014). Dose-dependent Modulation of Lipid Parameters, Cytokines and RNA by δ-tocotrienol in Hypercholesterolemic Subjects Restricted to AHA Step-1 Diet. Journal of Advances in Medicine and Medical Research, 6(4), 351–366. doi:10.9734/BJMMR/2015/13820

2) Shen CL, Yang S, Tomison MD, Romero AW, Felton CK, Mo H. Tocotrienol supplementation suppressed bone resorption and oxidative stress in postmenopausal osteopenic women: a 12-week randomized double-blinded placebo-controlled trial. Osteoporos Int. 2018;29(4):881-891. doi:10.1007/s00198-017-4356-x

3) Mahjabeen W, Khan DA, Mirza SA, Pervez MA. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial. Phytother Res. 2021;35(7):3968-3976. doi:10.1002/ptr.7113

4) Suleman F, Khan DA, Pervez MA, Aamir M. Effects of delta-tocotrienol supplementation on glycaemic control in individuals with prediabetes: A randomized controlled study. J Pak Med Assoc. 2022;72(1):4-7. doi:10.47391/JPMA.966

5) Shen CL, Mo H, Dunn DM, Watkins BA. Tocotrienol Supplementation Led to Higher Serum Levels of Lysophospholipids but Lower Acylcarnitines in Postmenopausal Women: A Randomized Double-Blinded Placebo-Controlled Clinical Trial. Front Nutr. 2021;8:766711. Published 2021 Dec 24. doi:10.3389/fnut.2021.766711

Healthy Bones Co. Annatrol™ Bone Support contains 300mg of premium and pure tocotrienols. Tocotrienols are a form of Vitamin E shown to help support cardiovascular health, inflammatory biomarkers, healthy cholesterol levels, glycemic control, bone health, and metabolic health*.

The term “Vitamin E” covers eight compounds grouped into tocopherols and tocotrienols, each with different chemistries and biological effects. Clinical studies show delta- and gamma-tocotrienols provide significant health benefits, but the commonly used alpha-tocopherol form interferes with delivery of those benefits. DeltaGold® Tocotrienols used in Annatrol™ Bone Support are derived from annatto, the only known plant containing tocotrienols with virtually no tocopherols present.

In addition to numerous other health benefits, Tocotrienols have been studied in a human clinical trial of postmenopausal osteopenia subjects and reductions in bone loss were observed. In this 12-week study of 87 postmenopausal women, DeltaGold® annatto tocotrienol was administered at dosages of 300 and 600mg/day. Both doses led to decreased bone resorption and improved bone formation. One bone biomarker, the BALP/NTX ratio, which is a measure of bone remodeling, increased 100% after 12 weeks. In addition, the RANKL/OPG ratio that indicates bone resorption is high was reduced 13-24% after 12 weeks, whereas this ratio increased 21-36% in the placebo group. Furthermore, the use of annatto tocotrienol for application in postmenopausal women was shown to be safe.

Healthy Bones Co. Annatrol™ Bone Support also contains 300mg of Geranylgeraniol (GG), a compound synthesized endogenously in the human body via the mevalonate pathway–the same biochemical pathway by which cholesterol, vitamin K2, steroid hormones and ubiquinone (CoQ10) are synthesized. As such, it plays a critical role in tissue systems and metabolic processes throughout the body, including healthy mitochondrial function and the generation of ATP–the currency of energy in all mammals including humans.

GG occurs naturally in various foods, but the majority is synthesized endogenously. GG is an essential building block that supports protein synthesis, muscle health, bone health, hormone regulation and CoQ10 synthesis. Production of GG declines naturally during aging and is inhibited by use of certain pharmaceutical drugs, namely, statins and bisphosphonates.

Vitamin K2, also known as menaquinone, comes in different forms like MK-4 and MK-7, each with a unique structure. MK-4 is the primary form found in the body and is crucial for managing calcium transport, especially to the bones. Many studies have now confirmed, Geranylgeraniol (GG) is required for the synthesis of MK-4 in the body.

By replenishing natural levels, GG can protect from age-related physical decline, maintain structural support for the body and revoke skeletal muscle fatigue. Extracted from the annatto plant, GG-Gold® found in Annatrol™ Bone Support can help replenish GG levels.

Annatrol™ Bone Support is 100% plant-based and provides the right amounts of Tocotrienols and GG to support your stronger bones goals.

Take 2 liquid capsules per day, or as directed by your health-care practitioner.